INSTACOATTM EN-SUPER-II is a fully formulated enteric coating system based on Methacrylic Acid Copolymer Type C. It is a patented product for aqueous reconstitution. It is recommended in the cases where phthalate esters such as CAP or HPMCP are not compatible or pose stability problems. Typically, a weight gain in the range 8 -12 % is sufficient to achieve reliable enteric protection.
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| INSTACOAT EN SUPER II | |
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All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
INSTACOATTM EN SUPER-II is a fully formulated enteric coating system based on Methacrylic Acid Copolymer Type C. It is a patented product for aqueous use. It is recommended in the cases where phthalate esters such as CAP or HPMCP are not compatible or pose other problems. Typically, a weight gain of around 9% provides reproducible delayed release profiles.
Purified water at up to 20% w/w solids
Variable-speed mechanical stirrer (do not use high-shear equipment)
Mixing Vessel
Determine the quantities of Instacoat EN SUPER-II (20% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 8% wt. gain, weigh 88 g Instacoat and 352 gm purified water at room temperature (includes 10% overage for losses).
Add the weighed quantity of water to a mixing vessel.
Using a mechanical stirrer, stir the purified water to form a vortex.
Add the required quantity of Instacoat EN SUPER-II to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex and completing powder dispersion within 5 minutes. Once this has been achieved, reduce the stirrer speed to eliminate the vortex and continue mixing for 45 minutes.
| Side-vented (fully perforated) pans | Conventional (non perforated) pans | |
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| Pan diameter (inch) | 24-60 | 12-36 |
| Tablet load (kg) | 10-300 | 0.5-50 |
| Weight gain (%) | 8-9 % | |
| Number of guns | 1-6 | 1-2 |
| Liquid nozzle diameter (mm) | 1.0-1.5 | |
| Atomising air pressure (bar) | 1.5-2.5 | |
| Pattern air pressure | To achieve maximum uniform bed coverage | |
| Tablet bed temperature (⁰C) | 30-35 | |
| Inlet air temperature (⁰C) | Set to achieve required product bed temperature | |
| Suspension spray rate | Set to achieve required product bed temperature | |
| Exhaust air volume | To maintain slight negative pressure in pan | |
| Pan speed | Minimum for steady tablet flow through spray zone | |
*Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
Methacrylic Acid Copolymer Type C; Plasticiser; Titanium Dioxide; Edible Pigments; Alkaliser; Glidant.