INSTACOATTM P4 is an alginate-based film coating system. This provides avoids the use of cellulose-based materials to avoid incompatibility or provide IP advantages. It is a dry blend of polymer, plasticizer and approved colours. It gives a glossy finish to tablets at weight gain values of around 2.0 to 3.0%. The system being robust can be handled with a variety of coating machines and processes without stringent processing conditions.
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All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
Variable-speed mechanical stirrer
Mixing Vessel
Determine the quantities of Instacoat P4 (20% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 132 gm purified water at room temperature (includes 10% overage for losses)
Add the weighed quantity of water to a mixing vessel.
Using a mechanical stirrer, stir the purified water to form a vortex
Add required quantity of Instacoat P4 to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. Continue mixing for 45 minutes.
| Parameters | Side-vented (fully perforated) pans | Conventional (non perforated) pans |
|---|---|---|
| Pan diameter (inch) | 24-60 | 12-36 |
| Tablet load (kg) | 10-300 | 0.5-50 |
| Weight gain (%) | 2.0 - 3.0% | |
| Number of guns | 1-6 | 1 |
| Liquid nozzle diameter (mm) | 1.0 - 1.2 | |
| Atomising air pressure (bar) | 3.0 - 4.0 | |
| Pattern air pressure | To achieve maximum uniform bed coverage | |
| Tablet bed temperature (°C) | 37 - 40 | |
| Inlet air temperature (°C) | Set to achieve required product bed temperature | |
| Suspension spray rate | Set to achieve required product bed temperature | |
| Exhaust air volume | To maintain slight negative pressure in pan | |
| Pan speed | Minimum for steady tablet flow through spray zone | |
*Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
Non-cellulosic water-soluble polymer(s); Plasticiser; Opacifier; Pigments; Glidant; Microbiological Preservative.