INSTACOATTM Universal is a unique film coating system consisting of a dry blend of polymers, plasticizers, pigments, opacifiers and other excipients. Its uniqueness lies in its ability to be used with variety of solvent systems such as organic solvents, hydro-alcoholic systems and aqueous systems.
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All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
Purified water at up to 11% w/w solids
Organic: I. IPA 35% + MDC 65% w/w at up to 5% solids II. Ethanol 35% + Chloroform 65% w/w at up to 5% solids
Hydro-alcoholic: Water 50% + IPA 50% w/w at up to 9%
Variable-speed mechanical stirrer
Mixing Vessel
Determine the quantities of Instacoat universal (11% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 267 gm purified water at room temperature (includes 10% overage for losses)
Determine the quantities of Instacoat universal (5% w/w solids) and IPA 35% + MDC 65% or Ethanol 35% + Chloroform 65% required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 627 gm IPA 35%+ MDC 65% or Ethanol 35% + Chloroform 65% at room temperature (includes 10% overage for losses)
Determine the quantities of Instacoat universal (9% w/w solids) and Water 50% + IPA 50% required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 3% wt. gain, weigh 33 g Instacoat and 333.67 gm Water 50% + IPA 50% at room temperature (includes 10% overage for losses)
Instacoat universal (Aqueous):
Add the weighed quantity of water to a mixing vessel.
Using a mechanical stirrer, stir the purified water to form a vortex
Add required quantity of Instacoat Aqua II to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. (Fig. 2) Continue mixing for 45 minutes.
Instacoat universal (Organic):
Add the weighed quantity of organic solvent to a mixing vessel.
Using a mechanical stirrer, stir the organic solvent to form a vortex
Add required quantity of Instacoat Universal to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. (Fig. 3) Continue mixing for 45 minutes.
Instacoat Universal (hydro alcoholic):
Add the weighed quantity of hydro alcoholic solvent to a mixing vessel.
Using a mechanical stirrer, stir the hydro alcoholic solvent to form a vortex
Add required quantity of Instacoat Universal to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex. Once the entire quantity of Instacoat has been added, reduce the stirrer speed to eliminate the vortex. (Fig. 4) Continue mixing for 45 minutes.
| Side-vented (fully perforated) pans | Conventional (non perforated) pans | |
|---|---|---|
| Pan diameter (inch) | 24-60 | 12-36 |
| Tablet load (kg) | 10-300 | 0.5-50 |
| Weight gain (%) | 1-6 | 1 |
| Liquid nozzle diameter (mm) | 1.0-1.2 | |
| Atomising air pressure (bar) | 2.5-3.5 | |
| Pattern air pressure | To achieve maximum uniform bed coverage | |
| Tablet bed temperature, Aqueous (⁰C) | 40-42 | |
| Tablet bed temperature, Organic (⁰C) | 36-38 | |
| Tablet bed temperature, Hydro-alcoholic (⁰C) | 38-40 | |
| Inlet air temperature (⁰C) | Set to achieve required product bed temperature | |
| Suspension spray rate | Set to achieve required product bed temperature | |
| Exhaust air volume | To maintain slight negative pressure in pan | |
| Pan speed | Minimum for steady tablet flow through spray zone | |
*Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
Water-soluble cellulosic polymer(s); Plasticiser; Titanium Dioxide; Edible Pigments, Glidant.