INSTACOATTM EN SUPER-IV is a fully formulated enteric coating system based on Methacrylic Acid and Ethyl Acrylate Co-polymer. It is recommended in the cases where phthalate esters such as CAP or HPMCP are not compatible or pose other problems. Typically, a weight gain of around 8% provides reproducible delayed release profiles.
Three separate formulations are available which are suitable for either fully aqueous, hydro-alcoholic, or fully organic solvent seems. With respect to solvent systems, the formulations are not interchangeable
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INSTACOAT EN SUPER IV |
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All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.
Please note that different formulations are provided according to the chosen solvent system. The individual formulations are not interchangeable between solvents.
INSTACOAT EN-SUPER IV (Aqueous)
INSTACOAT EN-SUPER IV (Organic)
INSTACOAT EN-SUPER IV (Hydro alcoholic)
Side-vented (fully perforated) pans |
Conventional (non perforated) pans |
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Aqueous | Organic | Hydro-alcoholic | Aqueous | Organic | Hydro-alcoholic | |
Pan diameter (inch) | 24-60 | 12-36 | ||||
Tablet load (kg) | 10-300 | 0.5-50 | ||||
Weight gain (%) | 8-0 % | |||||
Number of guns | 1-6 | 1 | ||||
Liquid nozzle diameter (mm) | 1.0-1.2 | |||||
Atomising air pressure (bar) | 1.5-2.5 | |||||
Pattern air pressure | To achieve maximum uniform bed coverage | |||||
Tablet bed temperature (⁰C) | 33-36 | 30-33 | 32-35 | 33-36 | 30-33 | 32-35 |
Inlet air temperature (⁰C) | Set to achieve required product bed temperature | |||||
Suspension spray rate | Set to achieve required product bed temperature | |||||
Inlet air volume | Set to achieve required bed temperature | |||||
Exhaust air volume | To maintain slight negative pressure in pan | |||||
Pan speed | Minimum for steady tablet flow through spray zone |
*Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.
Aqueous solvent: Methacrylic Acid Co-polymer Type C; Plasticiser; Titanium Dioxide; Edible Pigments; Glidant, Alkaliser, Surfactant